Causes of Acne:Acne is a disease of the pilosebaceous unit. It is a common disorders affecting both teenagers and adults, and is one of the most common disorders treated by the medical profession as well as self treatment using over the counter remedies. It can manifest itself as small comedones, blackheads, whiteheads, papules, pustules and deep cysts. There are numerous treatments available, which can vary from, but not limited too, systemic and topical antibiotics, retinoids, isotretinoin, and benzyl peroxide. Many of these treatments are effective if used for a sustained period of time. Most do not show immediate results which is often the goal of most patients.
Increase in stress is often associated with an acne
breakout. Recent scientific studies have shown that immunoreactive
nerve fibers in close proximity to the sebaceous glands generate a
neuropeptide called substance P that further stimulates the germative
sebocyte cells leading to an increase in the number of these cells and
in their differentiation .
The anaerobic bacterium pAcne can also be the source of the initial inflammation. Although studies have shown it is not necessary for pAcne to be present to start a microcomedone, its presence contributes to an inflammatory response . In acne lesions, human β defensis-1 and -2 are upregulated and serve as a protective mechanism against pathogens such as bacterias . It is reasonable to assume that pAcne bacteria is responsible for this increase in human β defensis-1 and -2. In addition Toll-like Receptors (TLR) manifested on macrophages are found in acne lesions. TLRs identify molecular patterns on bacteria and their presence is an indication that pACne bacteria have precipitated an inflammatory response.
All acne lesions start with the formation of a microcomedone created by hyperproliferation of the follicular epithelium . At this very early stage, inflammatory processes and activation of the vascular endothelium are present. This initial inflammatory event may have multiple causes, some of which or all of which may be present. Changes in the concentration of the lipids in sebum may be one factor . Peroxisome proliferator- activated receptor (PPAR) are transnuclear receptors responsible for generating peroxisome, which in turn are responsible for the catabolism of a variety of fats inside the cell. Studies linking androgens with PPAR in sebocytes suggest the increase production of free fatty acids and peroxidative squalene, both inflammatory compounds may be one cause . Other evidence also links androgens linking to PPAR in sebocytes with increase sebocyte differentiation and lipid generation. Free fatty acids in the cytoplasma of sebocytes also bind to PPAR leading to an increase in inflammatory compounds.
How the sebum is removed is also important. Since the dermal/epidermal barrier is compromised, any method that applies pressure on the sebum without a corresponding pressure on the dermis will force sebum out of the infundibulum into the dermis. This can occur using the traditional extraction methods. The key is to apply pressure on the dermis, thereby squeezing the sebum out of the infundibulum on to the surface of the skin. A vacuum chamber placed over the acne lesion would apply the right kind of pressure to the dermis surrounding the lesion and to the sebum contained in the lesion.
Although secondary to removing the sebum, the inflammation caused by acne has a major vascular component. Very small capillaries, produced in response to the inflammatory signaling, proliferate around and below the acne lesions. This increase in vasculature is detected as redness. Pulsed light of the proper wavelength and temporal duration is an ideal energy source for removing these vessels.
Theraclear and the causes of Acne:
The discussion above shows that whatever the cause of acne, the cause is in the sebum. Remove the sebum and the cause comes with it. Theraclear is the only device that removes the sebum.